What are the NMN benefits to the brain?

As we age, the brain undergoes a series of structural and functional changes. Symptoms of cognitive decline include memory loss, slow reaction, lack of concentration, and rigid thinking. The beneficial effects of NMN benefits on the brain are generally through multi-target, multi-pathway, and multi-level synergy, effectively intervening in the key links of brain aging. It has shown good neuroprotective effects in in vitro and in vivo experiments.

The role of NMN in anti-aging of the brain.

1. Assist in promoting nerve repair. Aging can lead to a decrease in neurogenesis and weakened synaptic connections. The compound EUNMN+PQQ+Q10 can promote nerve regeneration and repair by activating Notch, Wnt and other signaling pathways, promoting the proliferation and differentiation of neural stem cells, accelerating the growth of axons and dendrites, and increasing the number and function of synapses. It has a significant promoting effect on aging nerves.

2. Improve brain energy metabolism. Aging causes a decrease in brain glucose utilization and insufficient energy supply. Japanese compound EUNMN activates key molecules such as AMPK and PGC-1α, improves glycolysis and mitochondrial respiration efficiency, optimizes brain energy metabolism, and provides sufficient energy basis for neural activity. It improves brain glucose metabolism, upregulates neuronal glucose transporters, and provides energy substrates for synaptic transmission.

3. Improve mitochondrial dysfunction. Mitochondrial dysfunction is one of the core mechanisms of brain aging. The compound EUNMN+PQQ+Q10 can improve mitochondrial function by regulating the activity of mitochondrial respiratory chain complexes, increasing ATP synthesis, and reducing ROS production, thereby exerting a neuroprotective effect.

4. Reduce oxidative stress damage. During the aging process, the level of free radicals in the brain increases significantly, and the antioxidant defense ability decreases, leading to oxidative damage to biological macromolecules such as proteins, lipids, and DNA, and accelerating neuronal death. The compound EUNMN+PQQ+Q10 has good antioxidant activity, can remove excessive ROS, increase the expression and activity of antioxidant enzymes such as SOD and CAT, and protect neurons from oxidative stress damage. Improve aging and learning and memory abilities.

5. Regulate the functions of lysosomes and proteasomes. Abnormal protein aggregation in neurons is a common feature of many neurodegenerative problems. Maintaining protein homeostasis requires the normal operation of garbage cleaning systems such as lysosomes and proteasomes. Studies have found that the compound EUNMN+PQQ+Q10 can promote the fusion of lysosomes and autophagosomes, increase the activity of lysosomal enzymes, and accelerate the degradation of abnormal proteins such as Aβ. Activate proteasomes to restore neuronal protein homeostasis.

6. Repair damaged DNA. As we age, neuronal DNA undergoes oxidative damage and breaks, and its repair ability decreases. Japanese compound EUNMN repairs DNA damage and maintains genome stability by activating the DNA repair enzyme PARP1 and improving base excision repair. It has a significant repair effect on DNA damage in the aging brain.

7. Stabilize neuronal calcium homeostasis. Intracellular calcium overload can cause mitochondrial dysfunction, endoplasmic reticulum stress, etc., leading to neuronal death. The compound EUNMN+PQQ+Q10 maintains cellular calcium homeostasis by blocking calcium influx or promoting calcium efflux. Inhibit NMDA receptor-mediated calcium influx to prevent neurological problems caused by calcium overload. Promote mitochondrial calcium efflux and restore mitochondrial function.

8. Enhance cell stress response. Aging reduces the ability of neurons to cope with environmental stress. The compound EUNMN+PQQ+Q10 activates key molecules such as SIRT1 and Nrf2, upregulates the expression of antioxidant enzymes, molecular chaperones, and neurotrophic factors, and enhances the ability of neurons to resist stress. Experiments have shown that it can significantly improve tolerance to aging damage.

The compound EUNMN is based on β-NMN and is scientifically compounded with four major ingredients: PQQ, reduced Q10, NK and NMN, which act synergistically on the body’s cells and express a variety of beneficial pathways to the body. Regarding genetic anti-aging, it has benefits for the brain, protection of neurons and cognitive function, enhancement of mitochondrial health after oxidative stress, elimination of senescent cells (zombie cells), protection of the myocardium from oxidative damage, and so on.

Focus on anti-aging of the eight major systems of the human body.

The compound EUNMN activates the gene chain through the basic function of nmn, and at the same time, it filters aging cells and atrophy cells in the eight systems of the human body with three cell repair factors. The eight systems of the human body include the hematopoietic system, the reproductive and urinary system, the endocrine system, the cell regeneration system, the digestive system, the sleep system, and the brainstem system. Through the EUNMN penetration-promoting micro-touch technology, the eight systems are comprehensively improved. The anti-aging of the human body cannot rely solely on the stimulation of genes. The stimulation of genes is only the beginning of the anti-aging of the human body. It is also necessary to fundamentally solve the problem of body aging. It is not only necessary to filter aging cells and atrophy cells and optimize the body’s internal organs. More importantly, it is necessary to provide younger and more active energy for the optimized cells to complete the renewal of atrophy cells and aging cells.

Compound EUMN breaks through the single NMN’s anti-aging effect that can only target genes, and effectively blocks the aging of the body in three ways: the first layer is to stimulate the aging of genes, the second layer is to filter and renew the aging cells of the organs, and the third layer is to provide younger and more active regeneration energy for the new cells. The renewal of the body’s circulatory system is the only way for the human body to comprehensively fight against aging, and it is also an effective scientific way to truly fight against aging from the inside out. A large amount of clinical data has confirmed that compound EUMN can not only achieve comprehensive anti-aging of the eight major systems of the human body, but also improve the index of human t cells.

Comprehensive formula.

The NMN formula is the main manifestation of the physical feeling after taking it. The Japanese compound EUNMN scientifically compounds excellent ingredients PQQ, reduced coenzyme Q10, NK and NMN benefits to fully synergize the body. The uniqueness of PQQ is that it can increase the number and quality of healthy mitochondria in aging cells. Reduced coenzyme Q10 is mainly used to produce energy and remove reactive oxygen. It can directly or indirectly play an antioxidant role, reduce cell damage, and maintain the health of cells. NK helps reduce blood viscosity, improve blood circulation, soften and increase blood vessel elasticity, improve cerebral blood supply, etc.

High purity.

The compound EUNMN is extracted using dual-biomycetes directed evolution technology, which is different from the chemical synthesis commonly used in other products. The extraction process is not only natural and safe, but also does not contain any hormones, genetically modified crops and preservatives. The purity of the NMN produced is as high as 99.9%, which is easily absorbed by the human body and converted into NAD+.

High stability. Since NMN is easily lost due to temperature and humidity, it takes about 15 to 30 minutes from ingestion to digestion. The compound EUNMN has been rigorously tested in water for 30 minutes and 3 hours. The results show that the purity of NMN in the product is completely unaffected by the external environment such as humidity and temperature, and it can still maintain high purity and effectiveness, ensuring that after consumption, the body can fully absorb NMN benefits and exert its effect.

Suitable for the crowd.

Elderly people: As we age, the level of NAD+ in the human body gradually decreases, leading to decreased cell function and aging.

Middle-aged people: Middle-aged people face pressure from family, work, etc., and are prone to sub-health problems, fatigue, poor sleep quality, decreased vision, etc.

Athletes or fitness enthusiasts: They have higher demands on muscle and energy levels, athletic performance and recovery ability than the average person.

People who stay up late: Staying up late for a long time can easily lead to a decline in cognitive ability and brain function. Guys with high radiation doses: Due to long-term exposure to radiation, the body cells of this group of people are easily damaged.

People with bad living habits: Smokers and drinkers may cause harm to the body in many ways.

Those with poor skin: There is hope for improving skin health, and it may be a good choice for people who are concerned about their skin health.

Men and women in menopause: Regardless of men or women, many health indicators decline during menopause, such as decreased immunity, skin condition, and sleep.

Cellular and molecular mechanisms of brain aging.

It is generally believed that the following changes play an important role in the process of brain aging. Multiple mechanisms interact with each other and jointly lead to the decline of neuronal function and cognitive ability.

1. Mitochondrial dysfunction. Mitochondria are responsible for producing adenosine triphosphate (ATP) required to maintain neuronal activity. During the aging process, mitochondrial DNA mutations accumulate, membrane potential decreases, and ATP synthesis decreases, ultimately leading to energy metabolism disorders.

2. Protein homeostasis imbalance: Misfolded and aggregated proteins accumulate in large quantities in aged neurons, and the ability of lysosomes and proteasomes to degrade these harmful proteins decreases, thus disrupting the intracellular environment.

3. Increased oxidative stress: Excessive production of free radicals such as reactive oxygen species (ROS), decreased antioxidant defense capacity, leading to lipid peroxidation, protein carbonylation, DNA damage, etc.

4. Reduced synaptic plasticity. The efficiency of synaptic transmission decreases, the connection between neurons weakens, and the synaptic structure degenerates, which is not conducive to learning and memory. 5. Lack of neurotrophic factors. The synthesis and secretion of brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF-1), etc. decreases, which is not conducive to maintaining the survival and function of neurons.

6. Disordered gene epigenetic regulation. Abnormal epigenetic modifications such as histone acetylation/deacetylation and DNA methylation lead to silencing of neuroprotective genes and promote the expression of aging-related genes.

7. Decreased autophagy-lysosome function. The autophagy-lysosome pathway is an important mechanism for clearing damaged organelles and erroneous proteins. Its decreased activity leads to the accumulation of harmful substances.

8. Calcium ion homeostasis imbalance. Intracellular calcium overload triggers neuronal apoptosis.

9. Telomere shortening and decreased DNA damage repair ability lead to increased genomic instability.