What is collagen and, knowledge of type 3 collagen
Collagen is the main structural protein in the extracellular matrix of animal tissues, accounting for about 25% to 30% of the total protein, and is widely present in skin, bones, Achilles tendons and connective tissues .
There are 28 types of collagen report in the literature. The synthesis of collagen depends on the secretion of procollagen by fibroblasts, which is convert into tropocollagen molecules under the action of extracellular enzymes . Collagen contains a large amount of proline and lysine . With the assistance of O2, VC and Fe2+, it is convert into hydroxyproline and strong lysine through hydroxylation. They induce collagen cross-linking and glycosylation within or between tropocollagen molecules to form stable collagen fibers. Which are further tightly arrange and interwoven into a network to form elastic dermis, ligaments and vascular structures.
Collagen is a right-handed helical structure form by three chains. Natural collagen is insoluble in water, and there is no obvious difference in the molecular structure and physical and chemical properties of collagen of different types and animal sources.
Collagen is the main component of the extracellular matrix. The content and proportion of collagen are the main factors affecting tissue strength and tension. Type I and III collagen are the main components in the tissue, accounting for about 90% of the total collagen.
collagen type III
Why can’t the skin secrete collagen III? The collagen mother cells in the skin need external conditions during the differentiation process. They will transform into collagen III when they are weightless or attracted by low gravity . People spend much more time standing upright than lying down every day, so the collagen mother cells will secrete collagen I and ignore the secretion of collagen III. When people sleep more, they will find that their skin becomes smooth and tender. This is because after being attract by low gravity, more collagen III is secret. The amount of collagen secreted by the mother cells is lower than the amount lost, which causes the skin to become severely keratinized with age, and even mucosal wax paper-like changes. Therefore, collagen III must be supplement exogenously to restore the skin content to a youthful state. This is the importance of collagen III to the skin.
In fact, aging occurs simultaneously in multiple dimensions and levels. When you see the first fine lines on your body, irreversible and amazing changes have already occurred under the skin: reduction and displacement of facial soft tissue volume, weakening of skin ligament elasticity, degeneration of muscle strength, etc.
Three collagen loss problems
If we start counting from the peak period of 20, the total content of collagen III will decrease year by year with the increase of age, at a rate of 2% loss per year. Therefore, supplementing collagen III is not enough in one go. It needs to be supplement regularly to achieve youthful skin.
Why does collagen disappear?
There are many reasons for the loss of collagen, such as aging, damage from ultraviolet rays , environmental deterioration, irregular work and rest, high pressure from work and life, etc. In addition to the irresistible factor of aging, a major reason for the loss of collagen is the damage from ultraviolet rays, because ultraviolet rays can activate melanin and thus eat away at collagen. 3/5 The harm of collagen loss Collagen loss will first cause the skin to lose moisture.
If the skin is dehydrate and dry, wrinkles will appear, and makeup will easily get stuck. The skin will also lose elasticity, become loose and sagging, and the pores will increase. In addition, after collagen is swallow by melanin. If the activated melanin cannot be remove in time, it will also cause problems such as spots, uneven skin color, dullness or extremely sensitive skin. 4/5 How to slow down the loss of collagen Supplementing more foods containing collagen can also slow down its loss. Some foods containing colloid, such as beef tendons, pig trotters, chicken wings, chicken skin, fish skin and cartilage, are rich in collagen. In addition to internal collagen supplements, if you want to supplement collagen more effectively, you can choose some internal collagen drinks, because the molecular weight of liquid collagen is small and it is easily absorb by the human body.
Generally, the collagen content is between 1000D-2000D, and the effect is more obvious. In addition, another problem of collagen loss is due to ultraviolet radiation, so sun protection is also a top priority. 5/5 Women should not only have good looks, but also good skin. Buying a car requires regular maintenance, not to mention that women are the same. Women who know how to maintain themselves are exquisite!
What skin problems can be solve by supplementing collagen III
① Dull skin
②Solve rough skin
③Repair skin resistance (sensitive skin)
④Effectively treat fine wrinkles on the skin
⑤Effectively improve the darkness around the eyes (dark circles)
⑥Treat acne marks and acne pits
⑦Relieve facial spots such as sun spots, chloasma, brown-blue moles, etc.
⑧Treatment of skin scars
⑨ Gynecology: lighten areola pigmentation and vulva pigmentation, repair and increase mucosal resistance
Type III collagen to treat growth factor
The core mechanism of this technology of using human type III collagen to treat growth factor proliferation is that the body has the ability to degrade collagen on its own. In other words, when the skin is under tension, it secretes type 1 collagen and becomes hard; when there is no tension or when type 3 collagen increases, type 1 collagen feels that it is useless and degrades on its own. To put it more simply, it is just like human muscles. If you exercise regularly, the muscles will become harder due to mechanical stimulation; if you don’t exercise regularly, the muscles will atrophy. The same is true for the skin. In other words, do we rely on drugs to degrade the hyperplastic scar tissue, or do we rely on the body’s own homeostasis mechanism to allow it to degrade on its own?
Collagen is beneficial to the proliferation and differentiation of stem cells and cell attachment. It can aggregate into a fiber bundle structure, which serves as the attachment and scaffold for cell growth and promotes the cells to further synthesize new collagen and produce new ligament connective tissue, thereby strengthening the strength of the ligament root and rebuilding its own tissue. At the same time, the amino acid products after collagen degradation can further stimulate fibroblast proliferation and rebuild collagen fibers. Achieve a stable and long-term face lifting effect. The facial support ligament system is distribute around the bony cavity to support the facial SMAS layer, fat and skin, etc. The relaxation of the ligaments can lead to overall facial sagging.
These include true supporting ligaments and some false supporting ligaments. The true ligaments start from the periosteum and end from the skin.
The pseudo ligaments start from the soft tissue and end at the skin. Among them, the true ligaments are more important in maintaining the facial structure contour. Rapid collagen lifting at the roots of these ligaments can achieve the effects of mid-face lifting, tear troughs, eye bags, Indian lines, shallow nasolabial folds, and improved jawline contours.
Collagen III can also repair the damaged epidermis and is very good for treating sensitive skin. It can lock in moisture and repair the skin barrier for skin that has lost its resistance.
Sensitive skin is very difficult to treat. Dermatologists are most afraid of hormone face. Hormones must be use to control the acute stage. There is no other way. Hormonal dermatitis recurs for a long time. The most important cause is that collagen III is not repaired and supplement in time after peeling. Patients are very painful. With collagen III treatment, the effect is obvious, and the treatment methods are also rich.
The difference between type I collagen and type III collagen:
Human collagen is divide into more than 28 types according to different tissue locations, physiological functions, and molecular structures. The most widely studied and thoroughly researched types are type I, type II, and type III collagen. The collagen in human skin is type I collagen and type III collagen.
Type I collagen is the main component of normal adult skin (accounting for 80%), and collagen type I is mainly found in adult skin, tendons, and bone tissue. Type I collagen is coarse and forms thick fibrils with horizontal stripes in the body, which is the material basis for scar tissue fibrosis. During wound healing, type I collagen appears in large quantities, resulting in a scar structure that is completely different from normal skin tissue, with a hard texture and no elasticity; collagen is mainly synthesize by fibroblasts. But the fibroblasts of an adult’s own dermis can only synthesize type I collagen, which is why the proportion of type III collagen decreases while the proportion of type I collagen continues to increase during human growth.
Collagen type 1: Collagen type 1 is relatively coarse and is use to support the hardness of the skin and make it firm. However, if the content is too high, it will make the skin stiff and easily form scars after the wound heals.
Type II collagen is mainly found in cartilage, vitreous body, intervertebral disc, etc. This collagen: is closely related to the skin damage repair process and repair quality.
Type III collagen is the main collagen in fetal and infant skin (accounting for 60%). Collagen type III: mainly found in infant skin or vascular endothelium and intestine. Type III collagen is the main component of reticular fibers in the skin. The higher the content, the thinner the fiber bundles. In wound repair, the higher the proportion of type III collagen, the finer and smoother the skin tissue. The human body cannot produce type III collagen automatically or passively. It can only replenish the lost collagen III by direct irrigation in the dermis.
Collagen III: Collagen III is a small protein that is use to support the softness of the skin, making it delicate and elastic. The higher the content, the more delicate and tender the skin will be. After trauma, type III collagen can better restore the wound and is less likely to leave scars.
Three characteristics of collagen
①With two-way adjustment function:
According to the skin’s own needs, it can not only replenish the lost collagen III, but also synergistically transform it into collagen I
②Repair function:
Can repair damaged skin cells, such as barrier repair for sensitive skin
③ Anti-inflammatory and anti-infection of skin wounds, such as anti-inflammatory after surgery to prevent scars and infections, acute acne infections
④Improve skin microcirculation
The essence of human aging is that microcirculation disorders cause a decrease in blood supply to tissues and a weakening of the body’s cell repair ability, such as dark circles, spots, etc.
Indications of Qianzhenmei Second Generation Recombinant Humanized Type III Collagen
Suitable skin types include:
After the age of 22, the skin no longer produces and synthesizes type 3 collagen, so it must be supplement regularly to prevent premature aging.
Dehydrated dry skin
It is due to water loss that the skin becomes dry, wrinkled, and sensitive, so it is necessary to use recombinant human type 3 collagen containing a large number of hydrophilic amino acid groups to lock in moisture.
Oily skin with large pores
It is due to lack of water that causes excessive secretion of oil, resulting in oily skin and enlarged pores. The hydrophilic amino acid groups in recombinant human type 3 collagen can lock in moisture in the skin and balance water and oil. Type 3 collagen can also tighten enlarged pores and make them smaller.
Acne-prone skin
It is a skin problem cause by excessive oil secretion, inability of hair follicle keratin to shed normally, clogging pores, and bacterial reproduction and infection. Recombinant human type 3 collagen can balance water and oil, enhance immunity and eliminate bacterial infection. Combined with EGF , it can promote skin metabolism, restore the normal shedding of hair follicle keratin, and keep pores unobstructed.
Sensitive skin
This is a skin problem cause by skin damage and low immunity. Recombinant human type 3 collagen can enhance immunity and restore the skin’s normal immune function. Combined with EGF, it can promote basal cell regeneration and repair the skin’s complete defense barrier.
Red bloodshot skin
It is a skin problem cause by the damage of the stratum corneum and the thinning of its absolute thickness. Recombinant human collagen type 3 can quickly fill the damaged stratum corneum barrier and, combined with EGF, promote the regeneration of basal cells and replenish the number of missing stratum corneum cells, thereby restoring the physiological thickness of the stratum corneum and gradually eliminating the red blood streaks.
Pigmented skin
It is a skin problem cause by excessive secretion of melanin by melanocytes due to various stimuli. Recombinant human collagen type 3 maintains the normal migration of basal cells, and with EGF, promotes the regeneration of basal cells, so that cells containing excessive melanin quickly migrate to the stratum corneum and fall off, so that old spots fall off by themselves and new spots do not grow.
Sagging skin with true wrinkles
It is a skin problem cause by the loss of a large amount of type 1 collagen and type 3 collagen, which leads to the decrease in elasticity of the dermis fiber network structure and the shrinkage and breakage of fibers. Recombinant human collagen type 3 can not only directly supplement the missing type 3 collagen, but also cooperate with pentapeptide to allow fibroblasts to migrate to the broken fibers and produce a large amount of type 1 collagen, giving the skin elasticity, tightening loose skin, and shaping a three-dimensional contour. At the same time, the hydrophilic amino acid groups contained in it can lock the moisture in the dermis and keep the skin hydrated.
Dynamic Skin Texture
The expression lines formed on the skin due to the tension of the facial muscles. The hydrophilic amino acid groups contained in recombinant human collagen type 3 lock the moisture of the dermis and provide nutrition to the tense facial muscles. At the same time, it is combine with hexapeptide to soothe muscle nerves and dilute dynamic lines to prevent them from becoming real lines.
The difference between the second generation of recombinant humanized type III collagen
There are many brands of collagen III in the medical beauty consumables market. The difference between Qianzhenmei Collagen III and them is:
① As long as it contains collagen III, even if it is only 0.0001 mg, it can be called recombinant humanize collagen III.
② All calculated based on 5ml/bottle
Although the product containing 0.01 mg of collagen III and the Qianzhenmei Collagen III containing 40 mg of collagen III are both call collagen III, the treatment results between them are very different.
③ The price will be obviously different with different contents of main ingredients. Assuming that the content of Qianzhenmei Collagen III is 40 times that of other products, then the price of other products should be magnified 40 times to be the price of Qianzhenmei. Obviously, the price of Qianzhenmei Collagen III is very affordable (calculated based on the fact that other products contain 1mg in 5ml, the price is 95 yuan/5ml, then Qianzhenmei Collagen III 5ml contains 40mg, and the price should be 40 times that of other products.
④The three contents of collagen determine the quality and thus the clinical effect.
⑤ Collagen 3 is not afraid of large supplementation, but is afraid of small supplementation.
⑥ Type III collagen is the foundation, but how to make type III collagen play a unique effect is the joint efforts of clinical experts and material experts. After two years of continuous formulation experiments and hundreds of repeated clinical trials, we have obtained the Qianzhenmei products that have magical effects today. Qianzhenmei products are products that go from clinical to materials and then to clinical. The formula content ratio is continuously improved. After years of hard work, clinical and scientific research are perfectly combined.
It is also one of the highest products at present. The product jointly developed by the trinity of production, scientific research and clinical practice perfectly solves the problem of disconnection between the three. The formula comes from practice and goes back to practice. It is adjusted repeatedly to solve the nine major problems of skin aging in a targeted manner, opening up the limitations of the three applications of collagen!
Qianzhenmei Collagen III is currently developing skin supplements to prevent wound scars and infections after surgery. It is more effective than those imported from the United States (verified by Tianjin Medical Device Innovation Center) and more affordable. This also shows that Collagen III has obvious repair and degradation effects on collagen I (the main component of scars) without the need to grow.
Safety of Qianzhenmei’s second-generation recombinant humanized type III collagen
① The collagen of Qianzhenmei contains no large particles and is water-like, which will not cause wet or dry necrosis caused by local skin microcirculation embolism.
② After the three rollers of Qianzhenmei collagen open the skin barrier, it can be quickly absorbed by the small molecular weight
③Fast recovery after surgery without nodules
④No adverse reactions except protein allergy
⑤ The maintenance effect depends on the dosage and the patient’s skin condition. Generally, it can be maintained for more than 20 days at a time and can be maintained for about a year after saturation.
Why choose type III collagen for anti-aging
1. The effects of collagen injection on different layers of facial soft tissue are different
①It can be injected into the dermis to replenish the skin contents and make the skin bright and elastic
② Injection under the skin can repair microcirculation disorders and damaged skin appendages such as sweat glands and hair follicles, making the skin white and rosy, and inhibiting the production of pigments. Because it improves the microcirculation and soft tissue nourishment and increases the plumpness of the skin soft tissue, this is why it is used for a little filling effect.
③Injection into the true ligament of the face can repair the damaged ligament and make the ligament stronger, which is why there is a little lifting effect.
2. Differences between collagen and other products
① Skin aging process: the scaffold loosens (the collagen structure is loose) and the scaffold contents are lost (the collagen is lost). Just like the change of apples, fresh apples are fleshy and juicy, but after a period of time, the apple skin becomes wrinkled and dull (water loss_collagen three). After a period of time, the apple shrinks and collapses until it shrinks into a date pit or rots (plant fiber-collagen one).
The changes in the apple’s skin are the changes in the aging process of human skin
②Skin aging is like the change process of an apple
Dull skin, wilted skin, wrinkled skin, spots on the epidermis, sensitive and thin skin, shrinkage and sagging.
③Anti-aging methods
Photoelectric technology converts light energy into heat energy, such as Thermage, fractional, IPL, picosecond,
Water light micro needle (no drug)
Water light micro needle (with medicine)
All of them are products that repair collagen
The purpose of the above treatments is to stimulate the skin to regenerate and repair a large amount of collagen – a small amount of collagen – three. We collectively refer to the above treatments as regeneration stimulation skin anti-aging methods. This method accounts for more than 95% of skin anti-aging methods.
We call the method of supplementing skin anti-aging by replenishing non-cross-linked hyaluronic acid and collagen through microneedle injection and directly replenishing the lost scaffold contents. This method accounts for less than 5% of skin anti-aging methods. Regenerative treatment methods are already very complete.
Complementary treatments have just begun. For skin anti-aging methods, it must be a combination of the two, with each having its own emphasis, to better serve the skin rejuvenation of those who love beauty.
Differences between humanized type III collagen and allogeneic collagen
①Humanized collagen is collagen III produced by yeast fermentation instead of collagen I
② Heterogeneous collagen, such as pig and cow collagen, is mainly extracted from collagen 1.
③The two have different functions, one is mainly for skin anti-aging, and the other is mainly for effective subcutaneous filling
④ Safety: Yeast fermented collagen III (containing a small amount of collagen I) is safer, while allogeneic collagen has uncertain risks.
⑤ Different injection levels: collagen 3 is mainly injected into the dermis, while collagen 1 is mainly injected into the subcutaneous layer.
⑥Complications after injection: Collagen III has basically no injection risk except for protein allergy, while collagen I has the risk of embolism
The future trend of type III collagen
Collagen III is the main collagen component in human skin, fascia, and tendons, with a ratio of 4 to 1 to type I collagen. The protein is relatively small and exists between the epidermis and dermis. It is called “baby collagen” and is the key to supporting the epidermis and repairing skin collapse. Therefore, Qianzhenmei’s type III human-derived collagen can effectively act as a skin scaffold, thereby increasing protein, improving blood circulation, and enhancing the “screen window” effect, thereby increasing the gloss, fullness and firmness of the skin surface, truly achieving baby-like skin quality and reversing skin age.
Analysis of women’s skin care needs:
① If 20% cannot afford it, the awareness and financial resources do not allow it.
② If the 10% of the rich people look down on you and don’t like the universal price and treatment methods,
③ If 70% of people have a need, half of them choose other ways to care for their skin, and 10% make temporary changes.
The remaining 25%, how big a population is this? It is unimaginable that only 1% of them use collagen for skin anti-aging.
④ Decision cycle: trauma surgery takes three months, micro plastic surgery takes one month, and skin anti-aging can be decided by just thinking about the price.
⑤All women fall in love with medical beauty almost starting with skin care
⑥Risks are controllable, doctors prescribe and replicate, and the market is the largest
